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Semaglutide

Ranked 2 of 7 weight loss drugs by recommenders

People recommend it for effective weight loss and side benefits like less liver fat. Common caveats are nausea, stomach upset, and weight regain after stopping.

People recommend it for effective weight loss and side benefits like less liver fat. Common caveats are nausea, stomach upset, and weight regain after stopping.

68 people gave an opinion

recommend it
45
criticize it
23
approval share
66%
Each figure is one person. RecommendsCriticizes

Recommended in 7 of 13 months

  1. November 2025: recommended
  2. December 2025: not recommended
  3. January 2026: not recommended
  4. February 2026: recommended
  5. March 2026: not recommended
  6. April 2026: recommended
  7. May 2026: not recommended
  8. June 2026: recommended
  9. July 2026: recommended
  10. August 2026: recommended
  11. September 2026: recommended
  12. October 2026: not recommended
  13. November 2026: not recommended (month in progress)

Owned for 1 year

Median of the 10 owners who said how long they have had it.

Each square is one year.

Why it doesn’t carry the badge

  • 45 people recommend itNeeds 10 or more, met.
  • 1.95 recommenders for every criticNeeds 2 to 1 or better, not met.
  • Recommended in 7 of 13 monthsNeeds 4 or more, met.

The same three rules apply to every product, and the badge can’t be bought. How the badge works

What people say about it

The reasons people give, with the number of comments that give each one. Open a reason to read what they said.

Why people recommend it

Each mark is one comment

  • Helps autoimmune conditions

    “My own extremely rare and terribly painful immune disorder is basically entirely cured by it - it completely changed my life”

    Comment from 10 Feb 2026 in “Semaglutide improves knee osteoarthritis independant of weight loss”

    “It's a miracle drug for reducing immune overreach, like better than anything we know of.”

    Comment from 10 Feb 2026 in “Semaglutide improves knee osteoarthritis independant of weight loss”

    “I take low dose of semiglutide and this seems to help with the auto-immune aspect”

    Comment from 25 Apr 2026 in “A Collection of Chronic Medical Conditions Common in Autistic and ADHD Adults [pdf]”
  • Side effects minimal at low dose

    “As long as you stick to the lowest dose that's effective the side effects are minimal to non existent.”

    Comment from 28 Jun 2026 in “GLP-1 drugs led to weight loss and reversed depression-like behavior in mice”

    “Mine were mainly around bloating and abdominal pain, but I solved it by spacing the doses out further”

    Comment from 16 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

    “so far no serious unwanted side effects other than the usual ones for semaglutide which went away”

    Comment from 7 Apr 2026 in “Ah, peptides. where to begin?”
  • Effective weight loss

    “Weight loss is an extremely complicated and societally mediated problem that we didn't have a 'cheat code' like this for until recently.”

    Comment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

    “Losing 40 pounds where sometimes it feels like this weight is impossible to lose. That's what makes it worth it.”

    Comment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

    “"Just eat less" would work, but patients don't do that, so semaglutide it is.”

    Comment from 5 Sep 2026 in “Global warming will exceed 1.5-degree limit, UN says”
  • Reduces liver fat

    “It shrinks visceral fat, it's been shown to clear liver fat, and it actually increases mitochondrial efficiency”

    Comment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

    “Semaglutide cleared my liver fat and fixed my moderate NAFLD in a matter of months.”

    Comment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

What people warn about

Each mark is one comment

  • Low energy or hypoglycemia

    “After my first 10-day gap between doses I ended up with a strong encounter with the hypoglycemic feeling”

    Comment from 16 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

    “You aren't the only one I've heard who started to have no energy after being on semaglutide.”

    Comment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

    “Sema made me feel unwell and sometimes sleep due to what I think was hypoglycemia”

    Comment from 22 Mar 2026 in “The next wave of GLP-1 drugs coming.they're stronger than Wegovy and Zepbound”
  • Dementia benefit unproven

    “I'm not convinced by this study that GLP1 treatment reduces dementia incident rates meaningfully compared to normal health weight loss.”

    Comment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

    “Novo Nordisk's actual dedicated clinical trials for Alzheimer's completely failed to show that semaglutide stops cognitive decline.”

    Comment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

    “oral semaglutide did not significantly reduce clinical progression in patients with early symptomatic Alzheimer's disease”

    Comment from 17 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”
  • Stomach upset and gastroparesis

    “Mine were mainly around bloating and abdominal pain, but I solved it by spacing the doses out further”

    Comment from 16 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

    “I started at 0.025mg and still got temporary gastroparesis which was indeed very uncomfortable.”

    Comment from 26 Nov 2025 in “From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency”
  • Weight regain after stopping

    “We know that semaglutides have also side effects, and that rebound happen when you stop”

    Comment from 7 Jul 2026 in “Men's average testosterone levels have halved in last 50 years”

    “it's effective at losing weight but as soon as you stop you gain back all the weight”

    Comment from 25 Nov 2025 in “Ozempic does not slow Alzheimer's, study finds”

Other weight loss drugs people recommend

The four most recommended other weight loss drugs, with the same counts for each, so you can compare like for like. The tick on each bar marks the 2 to 1 line the badge needs.

Semaglutide compared with 4 alternatives
ProductRecommendCriticizeApprovalMonthsOwnedBadge
Ozempic523063%111.5 yrs6 owners—
SemaglutideThis page452366%71 yr10 owners—
Tirzepatide (Zepbound)36490%123 mo6 ownersApproved
Retatrutide23874%9—Approved
Wegovy231168%710 mo5 ownersApproved
See all 7 weight loss drugs, ranked

What people said

40 of the 86 comments that mention it, newest first. Each links to the original comment.

“"Just eat less" would work, but patients don't do that, so semaglutide it is.”

RecommendsComment from 5 Sep 2026 in “Global warming will exceed 1.5-degree limit, UN says”

“use of semaglutide and other GLP-1 medications in support of the above”

RecommendsComment from 23 Aug 2026 in “Ask HN: What's the current best research/understanding of healthy weight loss?”

“oral semaglutide did not significantly reduce clinical progression in patients with early symptomatic Alzheimer's disease”

CriticizesComment from 17 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“I strongly suspect that it has had an impact on my insulin sensitivity as well.”

RecommendsComment from 16 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“Mine were mainly around bloating and abdominal pain, but I solved it by spacing the doses out further”

MixedComment from 16 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“After my first 10-day gap between doses I ended up with a strong encounter with the hypoglycemic feeling”

CriticizesComment from 16 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“Overall I'm glad I took it and will continue to do so. It's not without downsides”

MixedComment from 16 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“It shrinks visceral fat, it's been shown to clear liver fat, and it actually increases mitochondrial efficiency”

RecommendsComment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“The only side effect I've had is nausea and it passes after a few minutes.”

MixedComment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“There's lots of studies not funded by Novo that show semiglutatide has reduced the incidence of dementia in the diabetes population.”

RecommendsComment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“I've now gone to a maintenance dose and seen my energy recover substantially”

MixedComment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“I'm not convinced by this study that GLP1 treatment reduces dementia incident rates meaningfully compared to normal health weight loss.”

MixedComment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“You aren't the only one I've heard who started to have no energy after being on semaglutide.”

CriticizesComment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“Weight loss is an extremely complicated and societally mediated problem that we didn't have a 'cheat code' like this for until recently.”

RecommendsComment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“It also doesn't need a fridge, so it allows me to travel more easily.”

RecommendsComment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“Losing 40 pounds where sometimes it feels like this weight is impossible to lose. That's what makes it worth it.”

RecommendsComment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“Novo Nordisk's actual dedicated clinical trials for Alzheimer's completely failed to show that semaglutide stops cognitive decline.”

CriticizesComment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“Semaglutide cleared my liver fat and fixed my moderate NAFLD in a matter of months.”

RecommendsComment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“We know that semaglutides have also side effects, and that rebound happen when you stop”

MixedComment from 7 Jul 2026 in “Men's average testosterone levels have halved in last 50 years”

“As long as you stick to the lowest dose that's effective the side effects are minimal to non existent.”

RecommendsComment from 28 Jun 2026 in “GLP-1 drugs led to weight loss and reversed depression-like behavior in mice”

“Semaglutide does an incredible job of keeping my autoimmune issues in check.”

RecommendsComment from 27 Jun 2026 in “GLP-1 drugs led to weight loss and reversed depression-like behavior in mice”

“I take low dose of semiglutide and this seems to help with the auto-immune aspect”

RecommendsComment from 25 Apr 2026 in “A Collection of Chronic Medical Conditions Common in Autistic and ADHD Adults [pdf]”

“I started at such low dose 0.025mg and ramped slowly I didn't expect to see much of an effect until I got to more normal doses”

MixedComment from 7 Apr 2026 in “Ah, peptides. where to begin?”

“so far no serious unwanted side effects other than the usual ones for semaglutide which went away”

RecommendsComment from 7 Apr 2026 in “Ah, peptides. where to begin?”

“semiglutide appears to help with autoimmune conditions in general”

RecommendsComment from 7 Apr 2026 in “Ah, peptides. where to begin?”

“Semaglutide has been the most effective and with it and a few others I am largely able to lead a normal life.”

RecommendsComment from 6 Apr 2026 in “Ah, peptides. where to begin?”

“Sema made me feel unwell and sometimes sleep due to what I think was hypoglycemia”

CriticizesComment from 22 Mar 2026 in “The next wave of GLP-1 drugs coming.they're stronger than Wegovy and Zepbound”

“Less anxiety about things i was hit by before and mood improved overall”

RecommendsComment from 11 Feb 2026 in “Semaglutide improves knee osteoarthritis independant of weight loss”

“the raw API on all of this stuff is coming from China in a way that is effectively unregulated”

MixedComment from 10 Feb 2026 in “Semaglutide improves knee osteoarthritis independant of weight loss”

“It's a common sign of snake oil when something claims to be the cure for a ton of completely unrelated conditions.”

MixedComment from 10 Feb 2026 in “Semaglutide improves knee osteoarthritis independant of weight loss”

“I'm having huge success on the medication and the slight issues I have are a worthy tradeoff personally.”

RecommendsComment from 10 Feb 2026 in “Semaglutide improves knee osteoarthritis independant of weight loss”

“My own extremely rare and terribly painful immune disorder is basically entirely cured by it - it completely changed my life”

RecommendsComment from 10 Feb 2026 in “Semaglutide improves knee osteoarthritis independant of weight loss”

“It's a miracle drug for reducing immune overreach, like better than anything we know of.”

RecommendsComment from 10 Feb 2026 in “Semaglutide improves knee osteoarthritis independant of weight loss”

“semaglutide reduces inflammation allowing the body to repair and improves mitochondrial function in cartilage cells”

RecommendsComment from 10 Feb 2026 in “Semaglutide improves knee osteoarthritis independant of weight loss”

“Seeing such an effect in just 9 weeks, 90% of that time being at low ramp up doses, is astonishing.”

RecommendsComment from 9 Feb 2026 in “Can Ozempic Cure Addiction?”

“saddles healthcare funding systems with an enormous burden for the next 20 years”

MixedComment from 26 Nov 2025 in “From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency”

“I started at 0.025mg and still got temporary gastroparesis which was indeed very uncomfortable.”

MixedComment from 26 Nov 2025 in “From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency”

“With slightly less reward from the body, the scales may tip slightly in favor of self control.”

RecommendsComment from 26 Nov 2025 in “From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency”

“it's effective at losing weight but as soon as you stop you gain back all the weight”

CriticizesComment from 25 Nov 2025 in “Ozempic does not slow Alzheimer's, study finds”

“The cardioprotective effects of semaglutide were independent of baseline adiposity and weight loss”

RecommendsComment from 12 Nov 2025 in “GLP-1 drugs linked to lower death rates in colon cancer patients”

Counts come from 1,795,640 Hacker News comments, November 2025 to November 2026. How we count. Report a mistake.