The best weight loss drugs, according to hackers
7 weight loss drugs were recommended on Hacker News between November 2025 and November 2026. We rank them by how many separate people recommend each one, and 5 earn the Hacker Approved badge.
Top picks
The three most recommended weight loss drugs with the badge. Each figure is 2 people. RecommendsCriticizes One comment
Reduces appetite and cravings
Recommended for large weight loss, reduced appetite and cravings, and better blood markers, often with fewer side effects than semaglutide; the common caveat is nausea and digestive side effects.
Effective for weight loss
Recommended for strong appetite suppression, weight loss and blood sugar control; people report strong results. Caveat: unapproved, sourced from unregulated sellers with uncertain purity.
Substantial weight loss and health gains
People recommend it for strong appetite suppression and weight loss, with reported health gains. Common caveat: side effects such as low mood and low motivation.
All 7 weight loss drugs, ranked
Select a column heading to sort. Approval share is recommenders out of everyone who gave an opinion; the tick on each bar marks the 2 to 1 line the badge needs. Months counts the months, out of 13, in which someone recommended it.
| Rank | |||||||
|---|---|---|---|---|---|---|---|
| 1 | Ozempic | 52 | 30 | 63% | 11 | 1.5 yrs6 owners | — |
| 2 | Semaglutide | 45 | 23 | 66% | 7 | 1 yr10 owners | — |
| 3 | Tirzepatide (Zepbound) | 36 | 4 | 90% | 12 | 3 mo6 owners | Approved |
| Tied 4 | Retatrutide | 23 | 8 | 74% | 9 | — | Approved |
| Tied 4 | Wegovy | 23 | 11 | 68% | 7 | 10 mo5 owners | Approved |
| Tied 6 | Zepbound | 21 | 4 | 84% | 8 | 1 yr5 owners | Approved |
| Tied 6 | Mounjaro | 21 | 3 | 88% | 8 | 10 mo7 owners | Approved |
How we rank
Rank is the number of separate people who recommend a product in a Hacker News comment over the past year. Someone who praises the same weight loss drug in five threads counts once.
The badge goes to weight loss drugs that at least 10 people recommend, with recommenders outnumbering critics at least 2 to 1, recommended in at least 4 of the 13 months.
Rankings are never for sale. We may earn a commission when you buy through our links. It never changes the order.