Retatrutide
Hacker ApprovedShares rank 4 of 7 weight loss drugs by recommenders
Recommended for strong appetite suppression, weight loss and blood sugar control; people report strong results. Caveat: unapproved, sourced from unregulated sellers with uncertain purity.
Recommended for strong appetite suppression, weight loss and blood sugar control; people report strong results. Caveat: unapproved, sourced from unregulated sellers with uncertain purity.
31 people gave an opinion
- recommend it
- 23
- criticize it
- 8
- approval share
- 74%
Recommended in 9 of 13 months
- November 2025: not recommended
- December 2025: recommended
- January 2026: recommended
- February 2026: recommended
- March 2026: recommended
- April 2026: recommended
- May 2026: recommended
- June 2026: recommended
- July 2026: not recommended
- August 2026: recommended
- September 2026: recommended
- October 2026: not recommended
- November 2026: not recommended (month in progress)
Why it carries the badge
- 23 people recommend itNeeds 10 or more, met.
- 2.9 recommenders for every criticNeeds 2 to 1 or better, met.
- Recommended in 9 of 13 monthsNeeds 4 or more, met.
The same three rules apply to every product, and the badge can’t be bought. How the badge works
What people say about it
The reasons people give, with the number of comments that give each one. Open a reason to read what they said.
Why people recommend it
Each mark is one comment
Effective for weight loss
“I have used retatrutide quite effectively for weight loss”
Comment from 19 Apr 2026 in “Notes from the SF Peptide Scene” “Overall I'm quite pleased with the effects”
Comment from 7 Apr 2026 in “Ah, peptides. where to begin?” “it is amazing how potent retatrutide is”
Comment from 14 May 2026 in “The Biochemical Beauty of Retatrutide: How GLP-1s Work” - Comment from 5 Jan 2026 in “Novo Nordisk launches Wegovy weight-loss pill in US, triggering price war”
- Comment from 13 Jan 2026 in “Ozempic reduced grocery spending by an average of 5.3% in the US”
Strong appetite suppression and less food noise
“you can mix different GLP1s to get the desired effect of appetite suppression, food noise and metabolic boost”
Comment from 3 Sep 2026 in “Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s” “reta immediately knocked off another 15. I track calories, and I had changed nothing.”
Comment from 21 Mar 2026 in “Heart Attack and Stroke Risk Jumps When People Stop Taking GLP-1s” “what reta does, is absolutely murders my food noise”
Comment from 21 Mar 2026 in “Heart Attack and Stroke Risk Jumps When People Stop Taking GLP-1s” Preserves muscle while losing fat
“I was very pleased to find that I was able to increase muscle mass while cutting the fat.”
Comment from 6 Apr 2026 in “Ah, peptides. where to begin?” “It causes less muscle loss/wasting which is a huge benefit over Tirz.”
Comment from 16 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk” Helps blood sugar and type 2 diabetes
“get research retatrutide which looks to be an actual cure for T2D by clearing liver fat”
Comment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk” “makes it one of the most effective ways to treat T2D”
Comment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”
What people warn about
Each mark is one comment
Unregulated sourcing and unverifiable contents
“If you have medical tirz available, you should have some serious reasons to jump into the unregulated shark tank.”
Comment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk” “there's no mechanism for your typical person to verify that they're getting what they think they're getting”
Comment from 7 Apr 2026 in “Ah, peptides. where to begin?” “compounding pharmacies offering reta and other unapproved peptides”
Comment from 8 Feb 2026 in “FDA intends to take action against non-FDA-approved GLP-1 drugs” Side effects and safety worries
“Reportedly retatruide doesn't cause nausea in as many people, but can still cause diarrhea.”
Comment from 28 Dec 2025 in “How Pfizer ended up passing on my GLP-1 work back in the early '90s” “They are neuro-active in the brain, and their effects I've decided are not worth it.”
Comment from 26 Nov 2025 in “There may not be a safe off-ramp for some taking GLP-1 drugs, study suggests” “Suffered some anhedonia towards the end but that went away ~1wk after stopping.”
Comment from 6 Apr 2026 in “Ah, peptides. where to begin?” - Comment from 7 Apr 2026 in “Ah, peptides. where to begin?”
Other weight loss drugs people recommend
The four most recommended other weight loss drugs, with the same counts for each, so you can compare like for like. The tick on each bar marks the 2 to 1 line the badge needs.
| Product | Recommend | Criticize | Approval | Months | Owned | Badge |
|---|---|---|---|---|---|---|
| Ozempic | 52 | 30 | 63% | 11 | 1.5 yrs6 owners | — |
| Semaglutide | 45 | 23 | 66% | 7 | 1 yr10 owners | — |
| Tirzepatide (Zepbound) | 36 | 4 | 90% | 12 | 3 mo6 owners | Approved |
| RetatrutideThis page | 23 | 8 | 74% | 9 | — | Approved |
| Wegovy | 23 | 11 | 68% | 7 | 10 mo5 owners | Approved |
What people said
40 of the 41 comments that mention it, newest first. Each links to the original comment.
“you can mix different GLP1s to get the desired effect of appetite suppression, food noise and metabolic boost”
“It causes less muscle loss/wasting which is a huge benefit over Tirz.”
“I'm not convinced reta really shows that greater of results than tirz though.”
“If you have medical tirz available, you should have some serious reasons to jump into the unregulated shark tank.”
“I hope Retatrutide pans out but encouraging people to hop on research chemicals”
“makes it one of the most effective ways to treat T2D”
“get research retatrutide which looks to be an actual cure for T2D by clearing liver fat”
“Fantastic drug and entirely reversible.”
“The All-American Retatrutide is (nearly) here to save us all thankfully.”
“Government funded, sourced and dosed should be somewhat safer than going to sketchy websites”
“I hope it stays available the rest of my life.”
“The drug is pretty much ideal: dose-response curve doesn't flatten too much”
“With reta I have more energy than normal and workout even more than usual.”
“These medications are incredible if you are overweight and need them. But they are not a panacea.”
“it is amazing how potent retatrutide is”
“You just don't want to eat as much and you want to eat healthier.”
“I have used retatrutide quite effectively for weight loss”
“there's no mechanism for your typical person to verify that they're getting what they think they're getting”
“By any common sense, that is an unhealthy pace to lose body weight.”
“early results seemed promising and safe”
“it's giving me real "vioxx" vibes of messing with too much at once”
“very widely used alternatives exist in the regulated market”
“Overall I'm quite pleased with the effects”
“most people switching to Triz and Reta”
“$120 for 10mg of reta is highway robbery.”
“I was very pleased to find that I was able to increase muscle mass while cutting the fat.”
“Suffered some anhedonia towards the end but that went away ~1wk after stopping.”
“I required doses of Reta higher than the 8mg top end used in clinical trials to get appetite suppression out of it”
“what reta does, is absolutely murders my food noise”
“reta immediately knocked off another 15. I track calories, and I had changed nothing.”
“It might be worth checking out Tirzepatide or Retatrutide once it is released”
“I attribute the loss of desire to drink primarily to the GLP-1.”
“about to be more (Retatrutide) that outperform all other medications in the class”
“compounding pharmacies offering reta and other unapproved peptides”
“works amazingly well, btw”
“It's tirzepatide with glucagon, both of which are sourced very easily and legally.”
“it's been pretty damn effective”
“My behaviour on retatrutide is far superior at getting me both total content and joy”
“Reportedly retatruide doesn't cause nausea in as many people, but can still cause diarrhea.”
“They are neuro-active in the brain, and their effects I've decided are not worth it.”
Counts come from 1,795,640 Hacker News comments, November 2025 to November 2026. How we count. Report a mistake.