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Retatrutide

Hacker Approved

Shares rank 4 of 7 weight loss drugs by recommenders

Recommended for strong appetite suppression, weight loss and blood sugar control; people report strong results. Caveat: unapproved, sourced from unregulated sellers with uncertain purity.

Recommended for strong appetite suppression, weight loss and blood sugar control; people report strong results. Caveat: unapproved, sourced from unregulated sellers with uncertain purity.

31 people gave an opinion

recommend it
23
criticize it
8
approval share
74%
Each figure is one person. RecommendsCriticizes

Recommended in 9 of 13 months

  1. November 2025: not recommended
  2. December 2025: recommended
  3. January 2026: recommended
  4. February 2026: recommended
  5. March 2026: recommended
  6. April 2026: recommended
  7. May 2026: recommended
  8. June 2026: recommended
  9. July 2026: not recommended
  10. August 2026: recommended
  11. September 2026: recommended
  12. October 2026: not recommended
  13. November 2026: not recommended (month in progress)

Why it carries the badge

  • 23 people recommend itNeeds 10 or more, met.
  • 2.9 recommenders for every criticNeeds 2 to 1 or better, met.
  • Recommended in 9 of 13 monthsNeeds 4 or more, met.

The same three rules apply to every product, and the badge can’t be bought. How the badge works

What people say about it

The reasons people give, with the number of comments that give each one. Open a reason to read what they said.

Why people recommend it

Each mark is one comment

  • Effective for weight loss

    “I have used retatrutide quite effectively for weight loss”

    Comment from 19 Apr 2026 in “Notes from the SF Peptide Scene”

    “Overall I'm quite pleased with the effects”

    Comment from 7 Apr 2026 in “Ah, peptides. where to begin?”

    “it is amazing how potent retatrutide is”

    Comment from 14 May 2026 in “The Biochemical Beauty of Retatrutide: How GLP-1s Work”
  • Strong appetite suppression and less food noise

    “you can mix different GLP1s to get the desired effect of appetite suppression, food noise and metabolic boost”

    Comment from 3 Sep 2026 in “Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s”

    “reta immediately knocked off another 15. I track calories, and I had changed nothing.”

    Comment from 21 Mar 2026 in “Heart Attack and Stroke Risk Jumps When People Stop Taking GLP-1s”

    “what reta does, is absolutely murders my food noise”

    Comment from 21 Mar 2026 in “Heart Attack and Stroke Risk Jumps When People Stop Taking GLP-1s”
  • Preserves muscle while losing fat

    “I was very pleased to find that I was able to increase muscle mass while cutting the fat.”

    Comment from 6 Apr 2026 in “Ah, peptides. where to begin?”

    “It causes less muscle loss/wasting which is a huge benefit over Tirz.”

    Comment from 16 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”
  • Helps blood sugar and type 2 diabetes

    “get research retatrutide which looks to be an actual cure for T2D by clearing liver fat”

    Comment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

    “makes it one of the most effective ways to treat T2D”

    Comment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

What people warn about

Each mark is one comment

  • Unregulated sourcing and unverifiable contents

    “If you have medical tirz available, you should have some serious reasons to jump into the unregulated shark tank.”

    Comment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

    “there's no mechanism for your typical person to verify that they're getting what they think they're getting”

    Comment from 7 Apr 2026 in “Ah, peptides. where to begin?”

    “compounding pharmacies offering reta and other unapproved peptides”

    Comment from 8 Feb 2026 in “FDA intends to take action against non-FDA-approved GLP-1 drugs”
  • Side effects and safety worries

    “Reportedly retatruide doesn't cause nausea in as many people, but can still cause diarrhea.”

    Comment from 28 Dec 2025 in “How Pfizer ended up passing on my GLP-1 work back in the early '90s”

    “They are neuro-active in the brain, and their effects I've decided are not worth it.”

    Comment from 26 Nov 2025 in “There may not be a safe off-ramp for some taking GLP-1 drugs, study suggests”

    “Suffered some anhedonia towards the end but that went away ~1wk after stopping.”

    Comment from 6 Apr 2026 in “Ah, peptides. where to begin?”

Other weight loss drugs people recommend

The four most recommended other weight loss drugs, with the same counts for each, so you can compare like for like. The tick on each bar marks the 2 to 1 line the badge needs.

Retatrutide compared with 4 alternatives
ProductRecommendCriticizeApprovalMonthsOwnedBadge
Ozempic523063%111.5 yrs6 owners—
Semaglutide452366%71 yr10 owners—
Tirzepatide (Zepbound)36490%123 mo6 ownersApproved
RetatrutideThis page23874%9—Approved
Wegovy231168%710 mo5 ownersApproved
See all 7 weight loss drugs, ranked

What people said

40 of the 41 comments that mention it, newest first. Each links to the original comment.

“you can mix different GLP1s to get the desired effect of appetite suppression, food noise and metabolic boost”

RecommendsComment from 3 Sep 2026 in “Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s”

“It causes less muscle loss/wasting which is a huge benefit over Tirz.”

RecommendsComment from 16 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“I'm not convinced reta really shows that greater of results than tirz though.”

MixedComment from 16 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“If you have medical tirz available, you should have some serious reasons to jump into the unregulated shark tank.”

MixedComment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“I hope Retatrutide pans out but encouraging people to hop on research chemicals”

MixedComment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“makes it one of the most effective ways to treat T2D”

RecommendsComment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“get research retatrutide which looks to be an actual cure for T2D by clearing liver fat”

RecommendsComment from 15 Aug 2026 in “Semaglutide linked to 26% lower 5-year predicted dementia risk”

“Fantastic drug and entirely reversible.”

RecommendsComment from 10 Aug 2026 in “Study links GLP-1 drugs to bigger jump in women's employment than a degree”

“The All-American Retatrutide is (nearly) here to save us all thankfully.”

RecommendsComment from 4 Aug 2026 in “Waymo – Dallas Open to All”

“Government funded, sourced and dosed should be somewhat safer than going to sketchy websites”

RecommendsComment from 18 Jun 2026 in “Ozempic and Wegovy linked to surprising drop in violent behavior”

“I hope it stays available the rest of my life.”

RecommendsComment from 15 May 2026 in “The Biochemical Beauty of Retatrutide: How GLP-1s Work”

“The drug is pretty much ideal: dose-response curve doesn't flatten too much”

RecommendsComment from 15 May 2026 in “The Biochemical Beauty of Retatrutide: How GLP-1s Work”

“With reta I have more energy than normal and workout even more than usual.”

RecommendsComment from 15 May 2026 in “The Biochemical Beauty of Retatrutide: How GLP-1s Work”

“These medications are incredible if you are overweight and need them. But they are not a panacea.”

MixedComment from 15 May 2026 in “The Biochemical Beauty of Retatrutide: How GLP-1s Work”

“it is amazing how potent retatrutide is”

RecommendsComment from 14 May 2026 in “The Biochemical Beauty of Retatrutide: How GLP-1s Work”

“You just don't want to eat as much and you want to eat healthier.”

RecommendsComment from 14 May 2026 in “The Biochemical Beauty of Retatrutide: How GLP-1s Work”

“I have used retatrutide quite effectively for weight loss”

RecommendsComment from 19 Apr 2026 in “Notes from the SF Peptide Scene”

“there's no mechanism for your typical person to verify that they're getting what they think they're getting”

CriticizesComment from 7 Apr 2026 in “Ah, peptides. where to begin?”

“By any common sense, that is an unhealthy pace to lose body weight.”

CriticizesComment from 7 Apr 2026 in “Ah, peptides. where to begin?”

“early results seemed promising and safe”

RecommendsComment from 7 Apr 2026 in “Ah, peptides. where to begin?”

“it's giving me real "vioxx" vibes of messing with too much at once”

CriticizesComment from 7 Apr 2026 in “Ah, peptides. where to begin?”

“very widely used alternatives exist in the regulated market”

CriticizesComment from 7 Apr 2026 in “Ah, peptides. where to begin?”

“Overall I'm quite pleased with the effects”

RecommendsComment from 7 Apr 2026 in “Ah, peptides. where to begin?”

“most people switching to Triz and Reta”

MixedComment from 6 Apr 2026 in “Ah, peptides. where to begin?”

“$120 for 10mg of reta is highway robbery.”

CriticizesComment from 6 Apr 2026 in “Ah, peptides. where to begin?”

“I was very pleased to find that I was able to increase muscle mass while cutting the fat.”

RecommendsComment from 6 Apr 2026 in “Ah, peptides. where to begin?”

“Suffered some anhedonia towards the end but that went away ~1wk after stopping.”

MixedComment from 6 Apr 2026 in “Ah, peptides. where to begin?”

“I required doses of Reta higher than the 8mg top end used in clinical trials to get appetite suppression out of it”

CriticizesComment from 21 Mar 2026 in “The next wave of GLP-1 drugs coming.they're stronger than Wegovy and Zepbound”

“what reta does, is absolutely murders my food noise”

RecommendsComment from 21 Mar 2026 in “Heart Attack and Stroke Risk Jumps When People Stop Taking GLP-1s”

“reta immediately knocked off another 15. I track calories, and I had changed nothing.”

RecommendsComment from 21 Mar 2026 in “Heart Attack and Stroke Risk Jumps When People Stop Taking GLP-1s”

“It might be worth checking out Tirzepatide or Retatrutide once it is released”

RecommendsComment from 20 Mar 2026 in “Heart Attack and Stroke Risk Jumps When People Stop Taking GLP-1s”

“I attribute the loss of desire to drink primarily to the GLP-1.”

RecommendsComment from 9 Feb 2026 in “Can Ozempic Cure Addiction?”

“about to be more (Retatrutide) that outperform all other medications in the class”

RecommendsComment from 8 Feb 2026 in “FDA intends to take action against non-FDA-approved GLP-1 drugs”

“compounding pharmacies offering reta and other unapproved peptides”

CriticizesComment from 8 Feb 2026 in “FDA intends to take action against non-FDA-approved GLP-1 drugs”

“works amazingly well, btw”

RecommendsComment from 13 Jan 2026 in “Ozempic reduced grocery spending by an average of 5.3% in the US”

“It's tirzepatide with glucagon, both of which are sourced very easily and legally.”

RecommendsComment from 8 Jan 2026 in “TikTok influencers fuelling parallel market for unlicensed weight-loss drug”

“it's been pretty damn effective”

RecommendsComment from 5 Jan 2026 in “Novo Nordisk launches Wegovy weight-loss pill in US, triggering price war”

“My behaviour on retatrutide is far superior at getting me both total content and joy”

RecommendsComment from 2 Jan 2026 in “A website to destroy all websites”

“Reportedly retatruide doesn't cause nausea in as many people, but can still cause diarrhea.”

MixedComment from 28 Dec 2025 in “How Pfizer ended up passing on my GLP-1 work back in the early '90s”

“They are neuro-active in the brain, and their effects I've decided are not worth it.”

CriticizesComment from 26 Nov 2025 in “There may not be a safe off-ramp for some taking GLP-1 drugs, study suggests”

Counts come from 1,795,640 Hacker News comments, November 2025 to November 2026. How we count. Report a mistake.