Ozempic

Long-term owners

I went from what felt like a slow but steady decline through middle age and now I feel 20 years younger

Jan 2026 · comment

It's a huge difference, as you say it's like being 15-20 years younger. Life changing.

Jan 2026 · comment

for me I've been taking a low dose for autoimmune related ME/CFS for about 4 years now

Oct 2026 · comment

What hackers pick instead

• SemaglutidePeople recommend it for effective weight loss and side benefits like less liver fat. Common caveats are nausea, stomach upset, and weight regain after stopping.45recommend
• Tirzepatide (Zepbound)Recommended for large weight loss, reduced appetite and cravings, and better blood markers, often with fewer side effects than semaglutide; the common caveat is nausea and digestive side effects.36recommend
• RetatrutideRecommended for strong appetite suppression, weight loss and blood sugar control; people report strong results. Caveat: unapproved, sourced from unregulated sellers with uncertain purity.23recommend
• WegovyPeople recommend it for strong appetite suppression and weight loss, with reported health gains. Common caveat: side effects such as low mood and low motivation.23recommend
• ZepboundPeople recommend it for reduced hunger and substantial weight loss, and say it helped them build new habits. The most common caveat is high cost, and some report side effects.21recommend

Every quote

The 40 most detailed of 94 comments. Each links to the original.

1. I went from borderline prehypertensive to perfect 105/70. You can't go on and off it at will though, since you'll get rebound high BP if you don't taper.

   Mixed · Aug 2026 · in “The brain may be about to have its Ozempic moment”

2. Ozempic appears to lower the risk of heart attacks and strokes in overweight people well beyond what weight loss alone would explain.

   Recommends · Nov 2025 · in “Ozempic does not slow Alzheimer's, study finds”

3. It has helped with my insulin resistance, but if I take anywhere near a weight loss dose my intestines slow so much

   Mixed · May 2026 · in “The Biochemical Beauty of Retatrutide: How GLP-1s Work”

4. a silver bullet for obesity and orders of magnitude more effective than anything up to a gastric band surgery

   Recommends · Aug 2026 · in “The Sloppification of Peptides”

5. I went from what felt like a slow but steady decline through middle age and now I feel 20 years younger

   Recommends · Jan 2026 · in “Ozempic reduced grocery spending by an average of 5.3% in the US”

6. it makes it easy to not eat but it gives you no useful habits to keep that up because it's so easy

   Mixed · Jan 2026 · in “Ozempic reduced grocery spending by an average of 5.3% in the US”

7. I lost 40 lbs with Ozempic and kept almost all of it off a year after stopping the drug.

   Recommends · Jan 2026 · in “People who come off slimming jabs regain weight four times faster than dieters”

8. I also sleep way better, and the heartburn I thought was just a part of life went from

   Recommends · Jan 2026 · in “Ozempic reduced grocery spending by an average of 5.3% in the US”

9. It's a huge difference, as you say it's like being 15-20 years younger. Life changing.

   Recommends · Jan 2026 · in “Ozempic reduced grocery spending by an average of 5.3% in the US”

10. Many Ozempic patients lose some bone density. That can be an issue as you age.

    Mixed · Jan 2026 · in “Ozempic reduced grocery spending by an average of 5.3% in the US”

11. it's extremely effective in treating addictions, including alcohol addiction

    Recommends · Mar 2026 · in “Ozempic Is About to Go Generic for Billions of People”

12. I lost 70 pounds and feel better than ever, with very little side effects.

    Recommends · Oct 2026 · in “Hair Loss Was Just the Start. Ozempic Users Are Also Reporting Nail Trouble”

13. Many people on Ozempic report better impulse control (food or otherwise).

    Recommends · Dec 2025 · in “Weight loss jabs: What happens when you stop taking them”

14. I attribute the loss of desire to drink primarily to the GLP-1.

    Recommends · Feb 2026 · in “Can Ozempic Cure Addiction?”

15. decreases urges for a very wide range of compulsive behaviors

    Recommends · Dec 2025 · in “The battle to stop clever people betting”

16. Dropped 20+kg with Ozempic and it boosted me to exercise.

    Recommends · Jun 2026 · in “GLP-1 drugs led to weight loss and reversed depression-like behavior in mice”

17. it does sometimes reduce cravings for drugs and alcohol

    Recommends · Mar 2026 · in “Ozempic Is About to Go Generic for Billions of People”

18. there are many more issues, like bile related issues and an increased risk of developing gallbladder stones

    Criticizes · Oct 2026 · in “Hair Loss Was Just the Start. Ozempic Users Are Also Reporting Nail Trouble”

19. without forming good habits and lifting weights you're a candidate for muscle loss and related injuries

    Criticizes · Jan 2026 · in “Ozempic Melted Away Weight–and the Idea of 'Body Positivity'”

20. GLP-1 drugs will have most users hooked for life because they don't have the discipline and motivation

    Criticizes · Jan 2026 · in “Ozempic reduced grocery spending by an average of 5.3% in the US”

21. I did an Ozempic stint and noticed my bone density had decreased to the bottom 3 percentile for my age

    Criticizes · Jan 2026 · in “Why have death rates from accidental falls tripled?”

22. needs to be taken forever as the vast majority of patients regain most or all of the weight

    Criticizes · Jan 2026 · in “Ozempic reduced grocery spending by an average of 5.3% in the US”

23. miserable side effects that started after a couple years that just progressively got worse

    Criticizes · Nov 2025 · in “From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency”

24. It's a life long commitment. As soon as you stop, you end up becoming your old self

    Criticizes · Jan 2026 · in “Ozempic reduced grocery spending by an average of 5.3% in the US”

25. just using Ozembic without changing your habits on the way can't be the right way

    Criticizes · Jun 2026 · in “GLP-1 drugs led to weight loss and reversed depression-like behavior in mice”

26. the drugs will never fix their willpower and only temporarily fix the symptoms

    Criticizes · Jan 2026 · in “Ozempic reduced grocery spending by an average of 5.3% in the US”

27. The health outcomes of these drugs are amazing, and I think they will be up there with the most important medications ever invented

    Recommends · Jan 2026 · in “Ozempic reduced grocery spending by an average of 5.3% in the US”

28. taking ozempic for life vs taking ozempic and 5 different medications for life when obesity related illnesses bite you in the ass

    Recommends · Apr 2026 · in “Why Has There Been So Little Progress on Alzheimer's Disease?”

29. for the overwhelming majority of people who are obese, being thin and not lifting weights would be an improvement health-wise

    Recommends · Jan 2026 · in “Ozempic Melted Away Weight–and the Idea of 'Body Positivity'”

30. All the side effects I've seen of GLP-1s are positive, and we've had diabetes patients taking them for much longer than that.

    Recommends · Jan 2026 · in “Ozempic reduced grocery spending by an average of 5.3% in the US”

31. Im not sure why theres such a diataste for just letting fat people take a pill/injection to lose weight.

    Recommends · Jan 2026 · in “Ozempic Melted Away Weight–and the Idea of 'Body Positivity'”

32. It's almost the same effect as the other pills on appetite, but without the side effects.

    Recommends · Nov 2025 · in “From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency”

33. An Ozempic cure might be just the right push needed for someone to start a healthy cycle

    Recommends · Jan 2026 · in “Ozempic reduced grocery spending by an average of 5.3% in the US”

34. for me I've been taking a low dose for autoimmune related ME/CFS for about 4 years now

    Recommends · Oct 2026 · in “Hair Loss Was Just the Start. Ozempic Users Are Also Reporting Nail Trouble”

35. Ozempic and similar drugs can help with that and there's no shame in using them.

    Recommends · Jan 2026 · in “Ozempic reduced grocery spending by an average of 5.3% in the US”

36. The only thing that finally brought down societal-wide obesity stats was GLP-1s.

    Recommends · Oct 2026 · in “Most advice is right for the person giving it”

37. while they have their place, are simply useful tools in the hands of doctors

    Mixed · Jan 2026 · in “People who come off slimming jabs regain weight four times faster than dieters”

38. It's a tool - it can be a force multiplier if you also make other changes.

    Mixed · Jan 2026 · in “Ozempic reduced grocery spending by an average of 5.3% in the US”

39. will by all available evidence be skinnier and healthier on a glp drug

    Recommends · Jun 2026 · in “GLP-1 drugs led to weight loss and reversed depression-like behavior in mice”

40. At least that you can make the suffering go away sometimes with meds.

    Recommends · Oct 2026 · in “Most advice is right for the person giving it”