# Tirzepatide (Zepbound, Mounjaro)

Hacker Approved page: https://hackerapproved.com/p/tirzepatide/

59 people recommended Tirzepatide (Zepbound, Mounjaro) in Hacker News comments, 13 had mixed feelings and 8 criticized it, November 2025 to October 2026. People who said how long they have used it report a median of 6 months, among 15 people. It was recommended in 11 of 12 months, in 37 threads. It does not meet the Hacker Approved badge rule.

These are opinions from Hacker News comments, not medical advice. Talk to a doctor.

**Verdict:** Recommended for large weight loss, reduced appetite and cravings, and better blood markers, often with fewer side effects than semaglutide; the common caveat is nausea and digestive side effects.

Summary written by Claude from 46 comments.

## Why people recommend it

- Reduces appetite and cravings (5 comments in the sample): "took me from always wanting food to actually being able to focus on other things fully" ([source](https://news.ycombinator.com/item?id=48703138)) "Totally helped me reduce appetite driven snacking and eating." ([source](https://news.ycombinator.com/item?id=47476489)) "the most striking effect was a marked decrease in cravings" ([source](https://news.ycombinator.com/item?id=49249348))
- Large weight loss reported (4 comments in the sample): "After losing a fair amount using tirzepatide, I did a repeat sleep test and my sleep doc gave me the green light to put the…" ([source](https://news.ycombinator.com/item?id=50167442)) "my weight was in a much better region, lipid panels were much improved" ([source](https://news.ycombinator.com/item?id=47685163)) "the massive improvement in my health that came with losing 100 pounds" ([source](https://news.ycombinator.com/item?id=49076071))
- Fewer side effects than semaglutide (4 comments in the sample): "Tirzepatide works, for me and I recommend it over semaglutide" ([source](https://news.ycombinator.com/item?id=47478357)) "found Tirzepatide strongly preferable to Semaglutide" ([source](https://news.ycombinator.com/item?id=48711349)) "tirzepatide had far fewer side effects for me" ([source](https://news.ycombinator.com/item?id=49313653))
- Improved blood markers and health (1 comment in the sample): "I've seen improvements in inflammation and other blood markers as well." ([source](https://news.ycombinator.com/item?id=49316664))

## What people warn about

- Nausea, stomach pain and diarrhea (3 comments in the sample): "I couldn't hit my macros on tirzepatide - couldn't get enough protein without feeling sick to my stomach." ([source](https://news.ycombinator.com/item?id=47462870)) "after twelve weeks I had to stop because I felt a lot of nausea and tenderness in my upper abdomen" ([source](https://news.ycombinator.com/item?id=48702412)) "It either gave me terrible diarrhea and sulfur burps, or it did nothing at all" ([source](https://news.ycombinator.com/item?id=48141741))
- Does nothing for some users (1 comment in the sample): "I am a rare nonresponder and have only gained weight." ([source](https://news.ycombinator.com/item?id=48141887))

## Other weight loss drugs people recommend

- [Semaglutide (Ozempic, Wegovy)](https://hackerapproved.com/p/ozempic/): 80 recommend, 24 mixed, 53 criticize
- [Retatrutide](https://hackerapproved.com/p/retatrutide/): 15 recommend, 7 mixed, 7 criticize

## The badge

A product earns the Hacker Approved badge when at least 10 people recommend it, recommenders outnumber critics at least 2 to 1 (mixed feelings count toward neither side), it was recommended in at least 4 of the 12 months and in at least 5 different threads, and no single thread supplies more than half of the people who recommend it. Health and money products are never badged.

## Cite as

Hacker Approved, "Tirzepatide (Zepbound, Mounjaro)", https://hackerapproved.com/p/tirzepatide/ (59 recommend, 13 mixed, 8 criticize; Hacker News comments, November 2025 to October 2026).

Counts updated 2 Nov 2026, with data through October 31, 2026.