Modafinil

Every quote

The 21 most detailed of 28 comments. Each links to the original.

1. For me it was a much stronger focus effect than caffeine and a much weaker effect than amphetamine.

   Mixed · Oct 2026 · in “The Other Epidemic: Trying to get off benzodiazepines”

2. a combination of weak ligands like Modafinil and Amitriptyline can really help with dysautonomia

   Recommends · Apr 2026 · in “A Collection of Chronic Medical Conditions Common in Autistic and ADHD Adults [pdf]”

3. The Modafinil / Amitryptiline is probably the most effective treatment I've tried

   Recommends · Jun 2026 · in “GLP-1 drugs led to weight loss and reversed depression-like behavior in mice”

4. I landed on Modafinil in the morning and Amitryptiline at night

   Recommends · Apr 2026 · in “Ah, peptides. where to begin?”

5. it was incredible for the most part and had zero side-effects

   Mixed · Aug 2026 · in “Reverse engineering my ADHD test”

6. 100mg modafinil makes me a LOT more productive

   Recommends · Feb 2026 · in “I Analyzed Every Nootropic Study on PubMed”

7. it's extremely effective at keeping you awake

   Recommends · Jul 2026 · in “How the Terrorist Group Boko Haram Uses Frontier AI”

8. effectively zero side effects

   Recommends · Nov 2025 · in “Aldous Huxley predicts Adderall and champions alternative therapies”

9. it's not even on the level of caffeine for stimulation

   Criticizes · Oct 2026 · in “The Other Epidemic: Trying to get off benzodiazepines”

10. Made a menu bar app you may find useful for MacBook sleep prevention, even when the lid is closed

    Recommends · May 2026 · in “Work with Codex from Anywhere”

11. it worked well when I took it but it was intense at the useful dose

    Mixed · Jul 2026 · in “It's getting harder to focus every day”

12. stops being effective as a performance enhancer pretty quickly

    Mixed · Oct 2026 · in “The Other Epidemic: Trying to get off benzodiazepines”

13. they seem better to me, but maybe long-term use is different

    Recommends · Nov 2025 · in “Aldous Huxley predicts Adderall and champions alternative therapies”

14. Modafinil has been a lifesaver for me for over a decade

    Recommends · Aug 2026 · in “The brain may be about to have its Ozempic moment”

15. which is what Modafinil does

    Recommends · May 2026 · in “Show HN: Modafinil - Let agents continue running while MacBook lid is closed”

16. no apparent tolerance build

    Mixed · Jun 2026 · in “GLP-1 drugs led to weight loss and reversed depression-like behavior in mice”

17. they last too long to really work with a normal 16/8 sleep cycle and the other stimmy effects can detract from things other than focus work

    Criticizes · Nov 2025 · in “Aldous Huxley predicts Adderall and champions alternative therapies”

18. we have some modafinil for that but now that you're developing early-stage dementia know that it's progressive.

    Criticizes · Nov 2025 · in “Ticker: Don't die of heart disease”

19. Studies show Modafinil isn't effective in ADHD adults.

    Criticizes · Sep 2026 · in “Reverse engineering my ADHD test”

20. Taking it made me not want to take it again.

    Criticizes · Dec 2025 · in “Why are 38 percent of Stanford students saying they're disabled?”

21. comes at a huge cost physically, mentally

    Criticizes · May 2026 · in “Creatine raise brain energy levels and slow Alzheimer's cognitive decline by 30%”