Lithium orotate
Ranked 7 of 10 dietary supplements by recommenders
Recommended as a supplement that reaches the brain and was effective in mouse models of Alzheimer's; human evidence is not cited in the quotes.
Recommended as a supplement that reaches the brain and was effective in mouse models of Alzheimer's; human evidence is not cited in the quotes.
8 people gave an opinion
- recommend it
- 7
- criticize it
- 1
- approval share
- 88%
Recommended in 4 of 13 months
- November 2025: not recommended
- December 2025: not recommended
- January 2026: not recommended
- February 2026: not recommended
- March 2026: not recommended
- April 2026: recommended
- May 2026: recommended
- June 2026: recommended
- July 2026: not recommended
- August 2026: not recommended
- September 2026: not recommended
- October 2026: recommended
- November 2026: not recommended (month in progress)
Why it doesn’t carry the badge
- 7 people recommend itNeeds 10 or more, not met.
- 7 recommenders for every criticNeeds 2 to 1 or better, met.
- Recommended in 4 of 13 monthsNeeds 4 or more, met.
The same three rules apply to every product, and the badge can’t be bought. How the badge works
What people say about it
The reasons people give, with the number of comments that give each one. Open a reason to read what they said.
Why people recommend it
Each mark is one comment
Effective in mouse models
“lithium orotate (a compound that reaches the brain) prevented it in a mouse model of Alzheimer's”
Comment from 23 May 2026 in “I Miss Terry Pratchett” “It won't hurt, but very well might help. It has been found to be effective in murine models.”
Comment from 15 Jun 2026 in “Copper transport drug restores memory and clears toxic Alzheimer's proteins” Low risk, possible benefit
“It won't hurt, but very well might help. It has been found to be effective in murine models.”
Comment from 15 Jun 2026 in “Copper transport drug restores memory and clears toxic Alzheimer's proteins” “the risk/reward profile looks so good from my perspective”
Comment from 26 Apr 2026 in “Why Has There Been So Little Progress on Alzheimer's Disease?”
What people warn about
Each mark is one comment
Felt unwell at 1mg daily
“my personal brain/body didn't react too well to 1mg a day”
Comment from 26 Apr 2026 in “Why Has There Been So Little Progress on Alzheimer's Disease?”
Other dietary supplements people recommend
The four most recommended other dietary supplements, with the same counts for each, so you can compare like for like. The tick on each bar marks the 2 to 1 line the badge needs.
| Product | Recommend | Criticize | Approval | Months | Owned | Badge |
|---|---|---|---|---|---|---|
| Creatine monohydrate | 104 | 51 | 67% | 8 | 1 yr21 owners | Approved |
| Melatonin | 43 | 24 | 64% | 8 | — | — |
| Magnesium glycinate | 31 | 7 | 82% | 8 | — | Approved |
| N-acetylcysteine (NAC) supplement | 17 | 5 | 77% | 5 | — | Approved |
| Lithium orotateThis page | 7 | 1 | 88% | 4 | — | — |
What people said
7 of the 8 comments that mention it, newest first. Each links to the original comment.
“Lithium Orotate for anxiety.”
“It won't hurt, but very well might help. It has been found to be effective in murine models.”
“lithium orotate (a compound that reaches the brain) prevented it in a mouse model of Alzheimer's”
“my personal brain/body didn't react too well to 1mg a day”
“1–5 mg lithium orotate, vitamin D, omega-3 from algae with high levels of polyphenols”
“Every time I read about it and get jazzed I take it and feel awful.”
“the risk/reward profile looks so good from my perspective”
Counts come from 1,795,640 Hacker News comments, November 2025 to November 2026. How we count. Report a mistake.