# Lithium orotate

7 Hacker News commenters recommended Lithium orotate and 1 criticized it, November 2025 to November 2026. It was recommended in 4 of 13 months.

**Verdict:** Recommended as a supplement that reaches the brain and was effective in mouse models of Alzheimer's; human evidence is not cited in the quotes.

## Why people recommend it

- Effective in mouse models (2 comments): "lithium orotate (a compound that reaches the brain) prevented it in a mouse model of Alzheimer's" ([source](https://news.ycombinator.com/item?id=48247933)) "It won't hurt, but very well might help. It has been found to be effective in murine models." ([source](https://news.ycombinator.com/item?id=48545438))
- Low risk, possible benefit (2 comments): "It won't hurt, but very well might help. It has been found to be effective in murine models." ([source](https://news.ycombinator.com/item?id=48545438)) "the risk/reward profile looks so good from my perspective" ([source](https://news.ycombinator.com/item?id=47907898))

## What people warn about

- Felt unwell at 1mg daily (1 comments): "my personal brain/body didn't react too well to 1mg a day" ([source](https://news.ycombinator.com/item?id=47909171))

## Alternatives hackers recommend

- [Creatine monohydrate](https://hackerapproved.com/p/creatine.md): 104 recommend
- [Melatonin](https://hackerapproved.com/p/melatonin.md): 43 recommend
- [Magnesium glycinate](https://hackerapproved.com/p/magnesium-glycinate.md): 31 recommend
- [N-acetylcysteine (NAC) supplement](https://hackerapproved.com/p/n-acetylcysteine.md): 17 recommend
- [Psyllium husk](https://hackerapproved.com/p/psyllium-husk.md): 13 recommend

## Cite as

Hacker Approved, "Lithium orotate", https://hackerapproved.com/p/lithium-orotate/ (counts from 1,795,640 Hacker News comments, November 2025 to November 2026).