AlphaFold

“It has been a true breakthrough solving a problem humanity as of then thought it was impossible to tackle.”

“we have seen AlphaFold solving a decades old protein folding problem”

“its main goal is precisely this. Combining up that tech with these pipelines is likely to speed things up”

“which gave use the folding of just about every protein we have ever found”

“Useful things like AlphaFold are getting conflated with LLM slop machines”

“it did far less for out of sample domains and it provides no intel into the kinetics of folding”

“AlphaFold is a bad analogy! AlphaFold has superhuman capabilities at one specialized subproblem”

“An enormous contribution to structural biology and biomedical research.”

“Our ability to predict what happens at these levels is improving by leaps and bounds too thanks to AI like AlphaFold”

“in practice not even alpha fold can tell me if my gfp fusion will work”

“these folding models fail when we don't have crystal structures, so they are certainly not generalizing”

“effectively obsoleted several experimental techniques overnight”

“Alphafold showed that you could take a physical process and make a neural net clever enough to learn just enough structure”

“one AI has already proved to help with breakthroughs (alphafold)”

“they did solve some math conjectures recently that the people working in the field for many years did not... Also AlphaFold.”

“This was a very big moment for science and yielded a nobel prize.”

“The big example predates LLMs as a unified tech and it's protein folding, from Google DeepMind.”

“it had little to do with the problem as it's been understood to mean”

“look to AlphaFold and the mega dataset of protein folds they have made available for science”

“Alphafold essentially solved the protein folding problem and it's arguably one of the biggest (if not the biggest) scientific achievements of the 21st century.”

“AlphaFold is a pretty big deal, especially the millions of protein folds they published openly”

“has already has had real impact on science with the same foundational architecture as LLMs, for protein folding”

“Alphafold2 was great but didn't actually 'solve' protein-folding”

“truly significant advancement of science that may lead to benefits for humanity and the planet”

“you still have to validate the structures it estimates, which minimises any speed gains”

“The work (leading and engineering) he and his team did with AlphaFold is astounishing”

“The crowning achievement of AI so far to me is not Claude Code, it's AlphaFold.”

“AlphaFold is an amazing machine learning approach to predicting protein structure”

“finally created computer systems that could handle biological systems like protein folding at an extraordinary level of capability”

“AI has produced AlphaFold which is kicking off a lot of progress in biology”

“what it outputs is a fundamentally a prediction with important limitations”

“If there's someone that can do something useful for humanity, it's Demis.”

“AlphaFold is effectively blind, it was just trained on correctly folded proteins with known structure.”

“there's a lot of real stuff happening like Waymos, Claude code, AlphaFold”

“Physical models are baked right into AlphaFold models and development at multiple steps, it is a highly unique architecture and approach.”

“Physical insights are built into the network structure, not just a process around it”

“we wouldn't have had the LLMs we use today if it wasn't for AlphaFold”

“probably the most impactful and positive thing to have come out of "Deep Learning" so far”

“the latter is an impressive achievment that really is optimization using a huge collection of prior knowledge”

“it is optimizing for "looking like a protein", not for "obeying physics"”